Daniel Wagenaar Thesis

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Activity patterns varied widely in terms of the frequency, intensity, duration, and degree of temporal clustering of bursts.

During the 2nd week in vitro, bursts in many dense cultures clustered into well-defined trains, separated by long periods without bursts.

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Past funding came from the Burroughs Wellcome Fund in the form of a Career Award at the Scientific Interface, from the University of Cincinnati and from The Broad Foundations.

All support, past and present, is gratefully acknowledged.

Globally synchronized bursting was observed in all but the most sparsely plated cultures.

A remarkable range of bursting behaviors was observed, even in cultures with identical plating parameters.

Let me begin by thanking Jerry Pine and Steve Potter, the best advisers I could have wished for.

From the moment I first stepped into Jerry’s lab, when I visited Caltech as a prospective, I knew it would be a good place to work.

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