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Defects in blood vessels manifest as red or purple spots and patches on the skin, rather than bleeding.The underlying abnormalities are either in the vessels themselves or in the perivascular connective tissue.
Acquired: Immunoglobulin Aassociated vasculitis, vitamin C deficiency, certain infections, steroid purpura, thinning of the skin as in Cushings syndrome.
Hereditary: Connective tissue disorders (such as Marfan syndrome and Ehlers-Danlos syndrome), hereditary hemorrhagic telangiectasia (rare autosomal dominant genetic disorder) and hemangiomas (noncancerous growths of blood vessels).
In the third patient the symptoms were milder and vanished without any specific treatment.
The levels of coagulation factor increased in all patients and the lupus anticoagulant disappeared within a couple of months.
However, some physicians and patients may choose to use other anticoagulant drugs because they have a reversal agent rather than using one of the Factor Xa inhibitors.
Having a safe and effective reversal agent available will benefit patients with acute bleeding." said the study's lead author. Bleeding diathesis can result from a number of reasons which include increased fragility of blood vessels, impaired wound healing, platelet deficiency or dysfunction, thinning of skin, coagulation, or a combination of these.
Coagulation tests revealed a shortened thromboplastin time (TT), long PT time, low level of coagulation factor II, and positive lupus anticoagulant among the antiphospholipid antibodies.
In one patient the clinical symptoms disappeared during a one-week course of prednisolone, another one received a prothrombin complex preparation as substitution therapy.
Bleeding disorders can be inherited (passed on from parent to child) or acquired in your lifetime.
There are three main components that are intrinsic to help the blood clot. Clotting disorders occur when there is a decreased activity of blood clotting factors which are proteins largely produced by the liver and by certain cells that line blood vessels.