In this section, you must quickly gain the reviewers’ trust and confidence while simultaneously convincing them that your work is important to fund.
Below is an example of an introductory paragraph: As the etiologic agent of adult T cell leukemia/lymphoma (ATLL), human T cell leukemia virus type I (HTLV-1) is just such a virus.
HTLV-1 encodes a potent oncoprotein, Tax, which regulates important cellular pathways including gene expression, proliferation, apoptosis, and polarity.
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This technique can be useful to emphasize the most important words or phrases in your Specific Aims page.
If you choose to use italics or to emphasize key points, remember to do so moderately.
The Specific Aims section is central to your grant proposal.
Therefore, it should be the first section you write.
Over the years, Tax has proven to be a valuable model system in which to interrogate cellular processes, revealing pathways and mechanisms that play important roles in cellular transformation.
Although the Tax oncoprotein has been shown to transform cells in culture and to induce tumors in a variety of transgenic mouse models, the mechanism by which Tax transforms cells is not well understood.