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As individuals live to advanced ages (e.g., over the age of 80), it can become more challenging to differentiate between the subtle cognitive declines that accompany aging and those that signify early dementia .
The trajectory of AD is characterized along a continuum, ranging from healthy aging to preclinical AD, mild cognitive impairment (MCI), and dementia.
Carroll | Sylvie Chalon | Anthony Gee | Alexander Gerhard | Christer Halldin | Karl Herholz | Matthias M. Knudsen | Bertrand Kuhnast | Francisco López-Picón | Rosa Maria Moresco | Sabina Pappata | Juha O.
Research Paper On Alzheimer Disease
Windhorst | Paul Edison | Ronald Boellaard | Oskar Hansson | Agneta Nordberg | Andreas H. Health care professionals should play a critical role in differentially diagnosing AD patients, as well as supporting their families.Novel interventions, including medications, natural supplements, and behavioral techniques, are constantly appearing in the literature.The transitional period between normal cognitive functioning and dementia is referred to as Mild Cognitive Impairment (MCI) ; the most common form, the one most likely to progress to AD, is amnestic MCI (a-MCI).Patients with a-MCI present with memory deficits greater than would be expected based on age and education; however functional abilities remain relatively preserved and independence intact .Estimates of the annual incidence of individuals with MCI progressing to dementia range from 5 to 15% .Regardless of this variation, annual conversion rate of those with MCI is far greater than the baseline incidence rate .Pathological changes that underlie AD begin to accumulate for years, or even decades, before emotional, physical, or cognitive symptoms emerge, eventually reaching a threshold at which the onset of a gradual and progressive decline in cognition occurs .Preclinical AD constitutes the presymptomatic phase during which characteristic neuropathological changes begin to emerge . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Due to the rise in the aging population, these figures are expected to double by 2050.