Vaccination Research Paper

One clue comes from an outbreak in a school in Essen, Germany, attended by children whose parents were opposed to vaccinations.

One clue comes from an outbreak in a school in Essen, Germany, attended by children whose parents were opposed to vaccinations.Of the 71 children infected with mumps, 68 had not been immunised.23But perhaps as important as the scare’s effect on infectious disease is the energy, emotion, and money that have been diverted away from efforts to understand the real causes of autism and how to help children and families who live with it.24There are hard lessons for many in this highly damaging saga. The GMC panel was clear that it was Wakefield alone who wrote the final version of the paper.

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Secondly, research ethics committees should not only scrutinise proposals but have systems to check that what is done is what was permitted (with an audit trail for any changes) and work to a governance procedure that can impose sanctions where an eventual publication proves this was not the case. In light of this new information their veracity must be questioned.

Finally, there are lessons for the Royal Free Hospital, the , and the wider scientific community. Past experience tells us that research misconduct is rarely isolated behaviour.25 Over the years, the have published a number of articles, including letters and abstracts, by Wakefield and colleagues.

Drawing on interviews, documents, and data made public at the GMC hearings, Deer shows how Wakefield altered numerous facts about the patients’ medical histories in order to support his claim to have identified a new syndrome; how his institution, the Royal Free Hospital and Medical School in London, supported him as he sought to exploit the ensuing MMR scare for financial gain; and how key players failed to investigate thoroughly in the public interest when Deer first raised his concerns.11Deer published his first investigation into Wakefield’s paper in 2004.12 This uncovered the possibility of research fraud, unethical treatment of children, and Wakefield’s conflict of interest through his involvement with a lawsuit against manufacturers of the MMR vaccine.

Building on these findings, the GMC launched its own proceedings that focused on whether the research was ethical.

But the size of this study — involving 657,461 Danish children born between 19 — should, in theory, bolster the argument that doctors and public health professionals still find themselves forced to make in the face of entrenched and growing resistance to vaccination in some quarters.

advertisement The work, published Monday in the Annals of Internal Medicine, was conducted by researchers at the Statens Serum Institut in Copenhagen.

The retraction statement cites the GMC’s findings that the patients were not consecutively referred and the study did not have ethical approval, leaving the door open for those who want to continue to believe that the science, flawed though it always was, still stands.

We hope that declaring the paper a fraud will close that door for good.

His coauthors seem to have been unaware of what he was doing under the cover of their names and reputations.

As the GMC panel heard, they did not even know which child was which in the paper’s patient anonymised text and tables. Although only two (John Walker-Smith and Simon Murch) were charged by the GMC, and only one, the paper’s senior author Walker-Smith, was found guilty of misconduct, they all failed in their duties as authors.